In general, probiotics are considered safe to take alongside Mounjaro (Tirzepatide). Probiotics primarily support gut health and digestion, while Mounjaro works to regulate blood sugar and appetite. There are no known direct interactions between the two. However, since Mounjaro can sometimes cause digestive side effects (such as nausea, bloating, or changes in bowel movements), introducing probiotics may impact how your gut responds. If you experience any discomfort or changes in digestion, you might consider starting with a lower dose of probiotics and gradually increasing as tolerated. As always, we recommend discussing any new supplements with your healthcare provider to ensure they align with your individual health needs.